Effects of modification of highly disperse silica with polyvinylpyrollidone on gelatin adsorption

The effects of surface modification of highly disperse silica with polyvinylpyrrolidone on its ability to adsorb gelatin were studied. This modification was found to produce a monotonic decrease in the proteopectic properties of silica resulting from changes in the nature of surface active centers....

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 44; no. 2; pp. 81 - 84
Main Authors Vasilenko, A. P, Guzenko, N. V, Nosach, L. V, Voronin, E. F
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.06.2010
Springer US
Springer
Subjects
adsorption modification
Chemical properties
gelatin adsorption
Highly disperse silica
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
polyvinylpyrrolidone
Silica
Silix
adsorption modification
gelatin adsorption
Highly disperse silica
Silix
polyvinylpyrrolidone
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Summary:The effects of surface modification of highly disperse silica with polyvinylpyrrolidone on its ability to adsorb gelatin were studied. This modification was found to produce a monotonic decrease in the proteopectic properties of silica resulting from changes in the nature of surface active centers. Changes in other pharmacologically important properties, i.e., rheological and hemolytic, resulting from modification of silica with polyvinylpyrrolidone, were extreme in nature. Thus modification produced strongly positive effects with minimal protein adsorption, indicating that PVP can be used as a modifier for creating new medicinal formulations based on highly disperse silica. The optimum level of modification of silica with polyvinylpyrrolidone was 20-30 mg/g, corresponding to about 15% of monolayer capacity.
Bibliography:http://dx.doi.org/10.1007/s11094-010-0403-z
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0403-z