Subcutaneous implantable cardioverter-defibrillator implantation position predicts successful defibrillation in obese and non-obese patients

• Published in: Journal of interventional cardiac electrophysiology
• Main Authors: Hoster, Clay, Rahman, Annas, Goyal, Ansh, Peigh, Graham, Trohman, Richard, Knight, Bradley P, Huang, Henry, Krishnan, Kousik, Larsen, Timothy, Mazur, Alexander, Sharma, Parikshit, Engelstein, Erica, Verma, Nishant, Wasserlauf, Jeremiah
• Format: Journal Article
• Language: English
• Published: Netherlands 03.01.2023
• Subjects: Obesity; PRAETORIAN; ICD; Defibrillation; S-ICD
• ISSN: 1572-8595; 1572-8595
• DOI: 10.1007/s10840-022-01462-z

Subcutaneous implantable cardioverter-defibrillators (S-ICD) are an alternative to transvenous ICDs for patients without a need for cardiac pacing. Obese patients have been proposed to be at higher risk for conversion failure with S-ICDs due to subcutaneous fat underneath the device. Optimal device positioning may promote equivalent outcomes between obese and non-obese patients by minimizing the effects of excess adipose tissue. A retrospective analysis of patients undergoing defibrillation testing at the time of S-ICD implantation was performed. The primary endpoint was the rate of successful conversion of ventricular fibrillation (VF) at the time of implant. The secondary endpoint was shock impedance. A total of 184 patients were included in the study. The rate of successful conversion of VF was 90.3% for obese patients (n = 72) and 96.4% for non-obese patients (n = 112) (p = 0.086). Compared to non-obese patients, obese patients had a higher mean PRAETORIAN score (78.5 ± 58.1 vs. 48.8 ± 35.5, p < 0.001) and higher measured mean impedance (82.0 ohms ± 26.5 vs. 69.8 ohms ± 19.3, p < 0.001). Patients with a PRAETORIAN score < 90 all had successful defibrillation testing regardless of BMI. In this study, a PRAETORIAN score < 90 was associated with a 100% success rate of defibrillation testing following S-ICD implantation regardless of patient body mass index (BMI). Thus, the impact of obesity on impedance and the risk of failed shocks may be minimized with close attention to implantation technique to achieve a low PRAETORIAN score.