Phytogenic synthesis of ZnO nanoparticles from Catharanthus Roseus and Morinda Citrifolia leaf extract and its promising multifunctional biological applications

• Published in: Journal of drug delivery science and technology Vol. 87; p. 104785
• Main Authors: Greeshma, K.P., Thamizselvi, R.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2023
• Subjects: Bio reduction; Biological assay; Catharanthus Roseus and Morinda Citrifolia; Zinc oxide nanoparticles; Bio reduction; Catharanthus Roseus and Morinda Citrifolia; Biological assay; Zinc oxide nanoparticles
• ISSN: 1773-2247
• DOI: 10.1016/j.jddst.2023.104785

Herein, we report the simple one-pot green route preparation of ZnO NPs (ZnO nanoparticles) from Morinda citrifolia and Catharanthus roseus ethanolic leaf extract and its synergic effect on multifunctional applications in anti-bacterial, anti-diabetic, antioxidant, anti-cancer properties and morphological changes in apoptosis induction. The structural and morphological confirmation of developed ZnO NPs studied by UV/Vis spectroscopy, SEM, FT-IR, XRD, EDAX, and TEM methods. Initial investigation on individual leaf extract-mediated ZnO nanoparticles were performed and their applications on biological systems was analysed. The combined leaf extract-mediated ZnO nanoparticles exhibit improved properties in all aspects and this led to further identification of these nanoparticles on apoptosis induction by double stained method. These novel results may be due to the morphology and appreciable particle size of ZnO nanoparticles. [Display omitted] •This work introduces a novel combination of leaf extract for the synthesis of ZnO nanoparticles.•The phytochemicals present in both plant extract act as reducing and capping agents and gave some morphological changes in the ZnO nanoparticles.•The synthesized combined leaf mediated ZnO utilized for the apoptosis induction MCF7 cell lines.•This study on plant extract may enlighten the development of nano drugs and their applications in the pharmaceutical industry.