Soft Electrodes for Electrochemical and Electrophysiological Monitoring of Beating Cardiomyocytes

Many cells in vivo have their inherent motions, which involve numerous biochemical and biophysical signals synergistically regulating cell behavior and function. However, existing methods offer little information about the concurrently chemical and physical responses of dynamically pulsing cells. He...

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Published inAngewandte Chemie International Edition Vol. 61; no. 26; pp. e202203757 - n/a
Main Authors Yan, Li‐Ping, Wen, Ming‐Yong, Qin, Yu, Bi, Chen‐Xi, Zhao, Yi, Fan, Wen‐Ting, Yan, Jing, Huang, Wei‐Hua, Liu, Yan‐Ling
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 27.06.2022
EditionInternational ed. in English
Subjects
Biocompatibility
Cardiomyocytes
Contractility
Electrical conductivity
Electrical resistivity
Electrochemical analysis
Electrochemical Sensor
Electrochemistry
Electrodes
Electrophysiology
Monitoring
Nitric Oxide
Rhythms
Soft Electrode
Electrophysiology
Cardiomyocytes
Electrochemical Sensor
Soft Electrode
Nitric Oxide
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Summary:Many cells in vivo have their inherent motions, which involve numerous biochemical and biophysical signals synergistically regulating cell behavior and function. However, existing methods offer little information about the concurrently chemical and physical responses of dynamically pulsing cells. Here, we report a soft electrode with an electrospun poly(3,4‐ethylenedioxythiophene) (PEDOT)‐based nanomesh to fully comply with spontaneous motions of cells. Moreover, this electrode demonstrated excellent electrical conductivity, electrochemical performance and cellular biocompatibility. Cardiomyocytes cultured thereon exhibited autonomous and rhythmic contractility, and synchronously induced mechanical deformation of the underlying electrode, which allowed real‐time monitoring of nitric oxide release and electrophysiological activity of cardiomyocytes. This work provides a promising way toward recording chemical and electrical signals of biological systems with their natural motions. A soft electrode with a PEDOT‐based nanomesh with excellent electrical conductivity, electrochemical performance and cellular biocompatibility is reported. It allowed the real‐time monitoring of both biomolecule release and electrophysiological activity of beating cardiomyocytes. This work provides a versatile platform for the simultaneous characterization of the chemical and electrical responses from dynamically pulsing cells.
Bibliography:These authors contributed equally to this work.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202203757