Glutathione‐Responsive Heterogeneous Metal–Organic Framework Hybrids for Photodynamic‐Gene Synergetic Cell Apoptosis

A core‐shell heterogeneous metal–organic framework (MOF) hybrid is sequentially designed by a photosensitized porous coordination network (PCN)‐typed MOF as core and Cu2+‐centered zeolitic imidazolate framework (ZIF‐67) as shell encapsulating cyanine 3‐labelled siRNA. The heterogeneous MOF hybrid re...

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Published inChemistry : a European journal Vol. 28; no. 31; pp. e202200305 - n/a
Main Authors Liu, Jintong, Córdova Wong, Bernardino J., Liu, Tianrui, Yang, Hong, Yao Ye, Lin, Lei, Jianping
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.06.2022
Subjects
Apoptosis
biosensors
Chemistry
Copper
Glutathione
heterogeneous structures
Hybrids
Metal-organic frameworks
Photodynamic therapy
Precision medicine
singlet oxygen
siRNA
Zeolites
biosensors
singlet oxygen
glutathione
heterogeneous structures
metal-organic frameworks
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Summary:A core‐shell heterogeneous metal–organic framework (MOF) hybrid is sequentially designed by a photosensitized porous coordination network (PCN)‐typed MOF as core and Cu2+‐centered zeolitic imidazolate framework (ZIF‐67) as shell encapsulating cyanine 3‐labelled siRNA. The heterogeneous MOF hybrid realized stimulus‐responsive photodynamic therapy (PDT) and controllable siRNA delivery through 1O2‐assistant endosomal escape for imaging‐guided photodynamic‐gene synergetic theranostics.
Bibliography:These authors contributed equally to this work.
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ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202200305