Controllable Disulfide Exchange Polymerization of Polyguanidine for Effective Biomedical Applications by Thiol‐Mediated Uptake

New preparation methods of vectors are the key to developing the next generation of biomacromolecule delivery systems. In this study, a controllable disulfide exchange polymerization was established to obtain low‐toxicity and efficient bioreducible polyguanidines (mPEG225‐b‐PSSn, n=13, 26, 39, 75, 1...

Full description

Saved in:
Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 61; no. 23; pp. e202200535 - n/a
Main Authors Zhu, Yiwen, Lin, Mengyu, Hu, Wenting, Wang, Junkai, Zhang, Zhi‐Guo, Zhang, Kai, Yu, Bingran, Xu, Fu‐Jian
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 07.06.2022
EditionInternational ed. in English
Subjects
Antibacterial
Antitumor
Biocompatibility
Biomedical materials
Controllable Disulfide Exchange Polymerization
Exchanging
Gene Delivery
Nucleic acids
Nucleophiles
Polyguanidine
Polymerization
Reaction time
Toxicity
Tumors
Wound Healing
Controllable Disulfide Exchange Polymerization
Antibacterial
Wound Healing
Antitumor
Gene Delivery
Online AccessGet full text

Cover

More Information
Summary:New preparation methods of vectors are the key to developing the next generation of biomacromolecule delivery systems. In this study, a controllable disulfide exchange polymerization was established to obtain low‐toxicity and efficient bioreducible polyguanidines (mPEG225‐b‐PSSn, n=13, 26, 39, 75, 105) by regulating the concentration of activated nucleophiles and reaction time under mild reaction conditions. The relationship between the degrees of polymerization and biocompatibility was studied to identify the optimal polyguanidine mPEG225‐b‐PSS26. Such polyguanidine exhibited good in vitro performance in delivering different functional nucleic acids. The impressive therapeutic effects of mPEG225‐b‐PSS26 were further verified in the 4T1 tumor‐bearing mice as well as the mice with full‐thickness skin defects. Controllable disulfide exchange polymerization provides an attractive strategy for the construction of new biomacromolecule delivery systems. A series of bioreducible polyguanidines (mPEG225‐b‐PSSn) was obtained by a controllable and efficient disulfide exchange polymerization by controlling the polarity of the polymerization solvent to regulate the concentration of the activated nucleophile. This approach provides an attractive and controllable strategy for the construction of bioactive substance delivery systems for effective biomedical applications.
Bibliography:These authors contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202200535