Synthesis and crystal structure of novel [1,2,4]oxadiazolo[5,4-d][1,5]benzothiozepine derivatives containing pyrazole moiety

• Published in: Journal of heterocyclic chemistry Vol. 48; no. 1; pp. 105 - 112
• Main Authors: Zhou, Ying-Lei, Shen, Song-Wei, Liu, Fang-Ming
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2011; Wiley
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; 1,3-DIPOLAR CYCLOADDITION REACTION; 2-PHENYL-1,2,3-TRIAZOLE; 1,5-BENZOTHIAZEPINES; NITRILE OXIDE
• ISSN: 0022-152X; 1943-5193
• DOI: 10.1002/jhet.520

A series of new substituted‐[1,2,4]oxadiazolo[5,4‐d][1,5]benzothiazepine derivatives containing pyrazole ring 4/4′ was synthesized by substituted‐pyrazolo[1,5]benzothiazepines 2/2′ and substituted‐benzohydroximinoyl chlorides 3 through the 1,3‐dipolar cycloaddition reaction in the presence of Et3N at room temperature, and characterized by MS, IR, 1H NMR and elemental analyses. In addition, the structure of 4′l was determined by X‐ray crystallography. J. Heterocyclic Chem., 2011.