Meningitis Among Neonates with Suspected Sepsis Presenting to Pediatric Emergency

We aimed to assess the risk factors, clinical features and microbial profiles of meningitis in neonates with suspected sepsis referred to a pediatric emergency. Over 13 months, 191 neonates were enrolled, of whom 64 (33.5%) had meningitis. There were no significant differences in risk factors or cli...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 42; no. 4; p. e124
Main Authors Soni, Prakash Kumar, Kumar, Jogender, Angrup, Archana, Kumar, Praveen, Saini, Shiv Sajan, Sundaram, Venkataseshan, Mukhopadhyay, Kanya, Dutta, Sourabh
Format Journal Article
LanguageEnglish
Published United States 01.04.2023
Subjects
Anti-Bacterial Agents - therapeutic use
Bacteria
Child
Humans
Infant
Infant, Newborn
Klebsiella pneumoniae
Meningitis - diagnosis
Meningitis - drug therapy
Microbial Sensitivity Tests
Sepsis - microbiology
Staphylococcus
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Summary:We aimed to assess the risk factors, clinical features and microbial profiles of meningitis in neonates with suspected sepsis referred to a pediatric emergency. Over 13 months, 191 neonates were enrolled, of whom 64 (33.5%) had meningitis. There were no significant differences in risk factors or clinical features between infants with and without meningitis. Ninety-three neonates (49%) had culture-positive sepsis (109 isolates). Candida spp. (n = 29), coagulase-negative staphylococci (n = 28) and Klebsiella pneumoniae (n = 23) were the most common pathogens. Forty-one (53%) bacteria were multidrug resistant.
ISSN:1532-0987
DOI:10.1097/INF.0000000000003816