Preparation of peptide and other biomolecular conjugates through chemoselective ligations

The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 751; p. 67
Main Authors Galibert, Mathieu, Renaudet, Olivier, Boturyn, Didier, Dumy, Pascal
Format Journal Article
LanguageEnglish
Published United States 2011
Subjects
Acetates - chemistry
Alkynes - chemistry
Azides - chemistry
Click Chemistry
Cyclization
Fatty Acids, Unsaturated - chemistry
Fluorenes - chemistry
Formic Acid Esters - chemistry
Glycosylation
Lactose - chemistry
Oxidation-Reduction
Oximes - chemistry
Peptides - chemical synthesis
Peptides - chemistry
Serine - chemistry
Substrate Specificity
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Summary:The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne-azide cycloaddition ("click") reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.
ISSN:1940-6029
DOI:10.1007/978-1-61779-151-2_6