Serum progesterone and norethisterone levels following injection of norethisterone enanthate in different sites and doses

• Published in: Steroids Vol. 53; no. 6; pp. 751 - 761
• Main Authors: Joshi, Jayashree V., Hazari, Kamal T., Shah, Rashmi S., Chadha, Usha C., Chitlange, Shanta, Gokral, Joyotsna S., Arolkar, Shubhangi G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.1989; Elsevier Science
• Subjects: Adult; Anovulation - chemically induced; Biological and medical sciences; Birth control; Contraceptives, Oral, Synthetic - administration & dosage; Contraceptives, Oral, Synthetic - pharmacology; Dose-Response Relationship, Drug; Female; Gynecology. Andrology. Obstetrics; Humans; Injections, Intramuscular; Medical sciences; Menstruation; Norethindrone - administration & dosage; Norethindrone - analogs & derivatives; Norethindrone - blood; Norethindrone - pharmacology; Other methods of contraception. Sterilization; Progesterone - blood; Human; Female; Contraceptive; Norethisterone; Progesterone; Sex steroid hormone; Pharmacokinetics; Progestational Hormones; Contraceptive Agents > pharmacodynamics; Progesterone > analysis; Contraceptive Agents, Female > pharmacodynamics; Laboratory Examinations And Diagnoses; Contraceptive Agents, Progestin > administraction and dosage; Contraceptive Agents > administraction and dosage; Contraceptive Methods > administraction and dosage; Biology; Contraception; Hormones; Family Planning; Examinations And Diagnoses; Contraceptive Agents, Progestin > analysis; Endocrine System; Injectables > administraction and dosage; Norethindrone Enanthate > pharmacodynamics; Contraceptive Agents, Progestin > pharmacodynamics; Contraceptive Agents, Female > administraction and dosage; Contraceptive Agents, Female > analysis; Contraceptive Agents > analysis; Physiology; Norethindrone Enanthate > administraction and dosage; Norethindrone > analysis
• ISSN: 0039-128X; 1878-5867
• DOI: 10.1016/0039-128X(89)90065-2

Serum progesterone (P) and norethisterone (NET) levels following injection of norethisterone enanthate (NETEN) were studied in 11 regularly menstruating women. In 6 subjects 200 mg NETEN was administered to the gluteal (IG) or deltoid (ID) region sequentially. The serum P levels remained anovulatory (<4 ng/mL) up to 12 weeks. Serum NET levels were similar whether injection was given IG or ID (paired t - test, NS). In 5 subjects given a 150-mg dose, serum P levels remained anovulatory up to 11 weeks. Serum NET levels declined faster than with the 200-mg dose, but the difference was not significant (Student's t - test, NS). Wide inter-subject variations were seen in both groups. NETEN therefore can effectively be administered in gluteal or deltoid regions. A lower dose of 150 mg may have contraceptive potential on an 8-week schedule.