A 1-heteroaryl-4-piperidinyl-methyl pyrrolidinone, BMY 21502, delays the decay of hippocampal synaptic potentiation in vitro

The effects of the substituted pyrrolidinone, BMY 21502, on the properties of cell membranes, synaptic transmission and synaptic plasticity, were assessed in area CA1 of hippocampal slices from the rat. Application of the compound to the bath had no consistent direct effects on parameters of the cel...

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Bibliographic Details
Published inNeuropharmacology Vol. 29; no. 11; p. 1001
Main Authors Gribkoff, V K, Bauman, L A, VanderMaelen, C P
Format Journal Article
LanguageEnglish
Published England 01.11.1990
Subjects
Aging
Animals
Hippocampus - drug effects
Hippocampus - growth & development
Hippocampus - physiology
In Vitro Techniques
Neurons - drug effects
Neurons - physiology
Psychotropic Drugs - pharmacology
Pyramidal Tracts - drug effects
Pyramidal Tracts - growth & development
Pyramidal Tracts - physiology
Pyrimidines - pharmacology
Pyrrolidinones - pharmacology
Rats
Rats, Inbred Strains
Synapses - drug effects
Synapses - physiology
Time Factors
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Summary:The effects of the substituted pyrrolidinone, BMY 21502, on the properties of cell membranes, synaptic transmission and synaptic plasticity, were assessed in area CA1 of hippocampal slices from the rat. Application of the compound to the bath had no consistent direct effects on parameters of the cell membrane or evoked synaptic potentials, at concentrations of less than 30 microM. In a blind experimental design, BMY 21502 at 1.0 and 10 microM, but not 25 microM, significantly delayed the decay of long-term potentiation in slices obtained from young animals; in slices obtained from very old rats (2.5-3.2 yr), 10 microM BMY 21502 significantly delayed decay of long-term potentiation. Therefore BMY 21502 was active in a physiological model that may predict of cognitive enhancement.
ISSN:0028-3908
DOI:10.1016/0028-3908(90)90105-Z