New Plant Species Showing Antiprotozoian Activity

• Published in: Doklady. Biochemistry and biophysics Vol. 507; no. 1; pp. 334 - 339
• Main Authors: Cheremnykh, E. G., Osipov, A. V., Starkov, V. G., Trang, Nguyen Thi Thuy, Khoa, Nguyen Cuu, Anh, Hoang Ngoc, Dung, Le Tien, Tsetlin, V. I., Utkin, Yu. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.12.2022; Springer Nature B.V
• Subjects: Antiprotozoal activity; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Ciliates; Life Sciences; Molecular Biology; Plant extracts; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plants - chemistry; Russia; Secondary metabolites; Tetrahymena pyriformis - drug effects; Russia; lilac; cinquefoil; antiprotozoal activity; elm; hop; nettle; chondrilla; licorice; wormwood; Tetrahymena pyriformis
• ISSN: 1607-6729; 1608-3091
• DOI: 10.1134/S160767292234004X

The effects of extracts of ten plant species from Russia and five species from Vietnam on the growth and survival of ciliates Tetrahymena pyriformis were studied. T. pyriformis belongs to the subkingdom Protozoa, which also includes pathogens of protozoan infections. Extraction of dried plants was carried out with acidic and alkaline aqueous solutions, as well as with an aqueous ethanol. Various amounts of extracts were added to the ciliate cells, and the number of cells survived after incubation for 1 and 24 h was recorded. We found that our samples of several plants, including wormwood, harmala, and licorice, similarly to those studied earlier, exhibit antiprotozoal activity, which may indicate that the secondary metabolites are the same in plants from different regions. Using the ciliate T. pyriformis as a model organism, the presence of antiprotozoal activity in extracts of lilac, chondrilla, cinquefoil, hop, and elm was shown for the first time.