Three isostructural solvates of finasteride and their solid-state characterization

Three crystalline hemi-hydrate, channel solvates (classified as solvates from here on) of finasteride (N-(1,1-di-methylethyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17beta-carboxamide) have been obtained and fully characterized. The acetone, methyl ethyl ketone (MEK), and toluene solvates of finasteride,...

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Bibliographic Details
Published inEuropean journal of pharmaceutical sciences Vol. 38; no. 5; pp. 498 - 503
Main Authors Schultheiss, Nate, Smit, Jared P, Hanko, Jason A
Format Journal Article
LanguageEnglish
Published Netherlands 08.12.2009
Subjects
Chemistry, Pharmaceutical - methods
Finasteride - analysis
Finasteride - chemistry
Pharmaceutical Solutions - chemistry
Solubility
Solvents
Stereoisomerism
X-Ray Diffraction - methods
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Summary:Three crystalline hemi-hydrate, channel solvates (classified as solvates from here on) of finasteride (N-(1,1-di-methylethyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17beta-carboxamide) have been obtained and fully characterized. The acetone, methyl ethyl ketone (MEK), and toluene solvates of finasteride, described herein, were found to be isostructural and belong as additional members to a family of previously reported finasteride solvates. Vacuum drying at 85 degrees C for 1 day produced the metastable, anhydrous Form II of finasteride from all three solvated materials.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0928-0987
1879-0720
DOI:10.1016/j.ejps.2009.09.014