Patterns of cellular proliferation during thyroid organogenesis

The changes in rate and location of cellular proliferation were analyzed to determineif localized areas of cell division were influencing shape changes in the chick thyroid. Pulse labeling with tritiated thymidine indicates that the gland's labeling index declines throughout its development. In...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 48; no. 1; pp. 269 - 286
Main Authors Smuts, M.S, Hilfer, S.R, Searls, R.L
Format Journal Article
LanguageEnglish
Published England Cambridge University Press for The Company of Biologists Limited 01.12.1978
Subjects
animal science
Animals
Cell Count
Chick Embryo
chickens
DNA - biosynthesis
embryo (animal)
livestock
Mitosis
Morphogenesis
Thyroid Gland - embryology
Time Factors
zoology
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Summary:The changes in rate and location of cellular proliferation were analyzed to determineif localized areas of cell division were influencing shape changes in the chick thyroid. Pulse labeling with tritiated thymidine indicates that the gland's labeling index declines throughout its development. Initially, the thyroid placode has a lower labeling index than the neighboring pharyngeal epithelium. An evaluation of the positions of pulse-labeled cells reveals that the evaginating thyroid grows by annexing cells from the pharyngeal epithelium. The older evaginated regions of the gland exhibit the lowest labelingindices. The newly acquired regions still maintain higher labeling indices.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-0752
0950-1991
1477-9129
DOI:10.1242/dev.48.1.269