Integral membrane proteins and dynamic organization of the nuclear envelope

The nuclear envelope is a complex structure consisting of nuclear membranes, nuclear pore complexes and lamina. Several integral membrane proteins specific to the nuclear pore membrane and the inner nuclear membrane are knon. Pore membrane proteins are probably important for organization and assembl...

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Bibliographic Details
Published inTrends in Cell Biology Vol. 4; no. 4; pp. 127 - 131
Main Authors Gerace, Larry, Foisner, Roland
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1994
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Summary:The nuclear envelope is a complex structure consisting of nuclear membranes, nuclear pore complexes and lamina. Several integral membrane proteins specific to the nuclear pore membrane and the inner nuclear membrane are knon. Pore membrane proteins are probably important for organization and assembly of the nuclear pore complex, while proteins of the inner nuclear membrane are likely to play major roles in the structure and dynamics of the nuclear lamina and chromatin. Biochemical studies are now identifying potential binding partners for some of these integral membrane proteins, and analysis of nuclear envelope assembly at the end of mitosis is providing important insights into their functions.
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ISSN:0962-8924
1879-3088
DOI:10.1016/0962-8924(94)90067-1