Human intestinal epithelial response(s) to Clostridium difficile

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 646; p. 135
• Main Authors: Jafari, Nazila V, Allan, Elaine, Bajaj-Elliott, Mona
• Format: Journal Article
• Language: English
• Published: United States 2010
• Subjects: Bacterial Proteins - immunology; Bacterial Toxins - immunology; Caco-2 Cells; Cell Line, Tumor; Clostridium difficile - immunology; Enterotoxins - immunology; Enzyme-Linked Immunosorbent Assay; HT29 Cells; Humans; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction

Clostridium difficile is a gram-positive, spore-forming, toxin-producing anaerobic bacillus that is being increasingly implicated as the leading cause of diarrhea and colitis, particularly in hospitalized, elderly patients. Studies to date suggest that C. difficile toxins A and B play a major role i...