Modern outlook on morphological criteria of organ and tissue decellularization

A rapidly growing development of tissue engineering promotes the increasing interest in the obtainment of various decellularizedtissues and organs. Minimal quality evaluation criteria of obtained tissue engineered constructions have been previously specified. In the discussionpaper the group of auth...

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Published inVestnik transplantologii i iskusstvennykh organov Vol. 19; no. 3; pp. 65 - 69
Main Authors A. S. Sotnichenko, E. A. Gubareva, E. V. Kuevda, I. S. Gumenyuk, I. V. Gilevich, R. Z. Nakokhov, A. A. Slavinskiy, S. N. Alekseenko
Format Journal Article
LanguageEnglish
Russian
Published Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 17.09.2017
Subjects
decellularization
heart
regenerative medicine
tissue engineering
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Summary:A rapidly growing development of tissue engineering promotes the increasing interest in the obtainment of various decellularizedtissues and organs. Minimal quality evaluation criteria of obtained tissue engineered constructions have been previously specified. In the discussionpaper the group of authors considers the morphological methods of matrix evaluation applied by various researchers on the model of heart decellularization. The analysis of modern literature and the authors’ own researches have shown that morphological evaluation of decellularization quality has to be complex and should consist of several stages which include both basic and additional evaluation methods.
ISSN:1995-1191
DOI:10.15825/1995-1191-2017-3-65-69