Concurrent Subcutaneous Panniculitis-like T-Cell Lymphoma and B-Cell Acute Lymphoblastic Leukemia in 2 Pediatric Patients

• Published in: Journal of pediatric hematology/oncology Vol. 43; no. 6; p. e791
• Main Authors: Smith, Geoffrey A, Levinson, Anya L, Galvin, Robert T, Lalor, Leah E, McCalmont, Timothy, Wang, Linlin, Geis, Michael C, Odegaard, Karah, Hupp, Meghan, Maguiness, Sheilagh, Turcotte, Lucie M, Cordoro, Kelly M, Hermiston, Michelle L
• Format: Journal Article
• Language: English
• Published: United States 01.08.2021
• Subjects: B-Lymphocytes - pathology; CD8-Positive T-Lymphocytes - pathology; Child, Preschool; Female; Humans; Lymphoma, T-Cell - complications; Lymphoma, T-Cell - diagnosis; Lymphoma, T-Cell - pathology; Male; Panniculitis - complications; Panniculitis - diagnosis; Panniculitis - pathology; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - diagnosis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology
• ISSN: 1536-3678
• DOI: 10.1097/MPH.0000000000001921

Subcutaneous panniculitis-like T-cell lymphoma is a cutaneous lymphoma characterized by CD8+ T-cell infiltrate in the subcutis that is rare in children. Acute lymphoblastic lymphoma is the most common pediatric malignancy and often presents with fevers and pancytopenia. Herein, we report 2 pediatric patients presenting with subcutaneous panniculitis-like T-cell lymphoma and B-cell acute lymphoblastic lymphoma, distinct hematologic malignancies arising from different lymphoid lineages, with no identifiable germline cancer predisposition.