Synthesis, physical-chemical properties and the study of anti-hypoxemic activity of 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion alkylderivatives

Heterocyclic systems, in particular, 1,2,4-triazole derivatives cause great interest in the development of new medicinal substances for the production of highly effective and safe antihypoxants. This fact has created favorable basis for the synthesis of new alkylderivatives 5-(adamantane-1-yl)-4-R-1...

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Published inZaporozhskiĭ medit͡s︡inskiĭ zhurnal no. 2; pp. 93 - 96
Main Authors Odyntsova, V. M., Pruglo, Ye. S.
Format Journal Article
LanguageEnglish
Published Zaporozhye State Medical University 27.04.2015
Subjects
anti-hypoxemic activity
derivatives
physical-chemical properties
triazole
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Summary:Heterocyclic systems, in particular, 1,2,4-triazole derivatives cause great interest in the development of new medicinal substances for the production of highly effective and safe antihypoxants. This fact has created favorable basis for the synthesis of new alkylderivatives 5-(adamantane-1-yl)-4-R-1,2,4-triazole-3-thion, where R is methyl, phenyl. Aim. In order to identify the most promising active compounds the pharmacological screening of anti-hypoxemic activity of synthesized compounds has been carried out. Results. Due to the results of the study a number of compounds with anti-hypoxemic activity have been revealed. Some regularities between structure and pharmacological effect have been established. Conclusion. This demonstrates the prospects of further studies of the obtained compounds.
ISSN:2306-4145
2310-1210
DOI:10.14739/2310-1210.2015.2.42123