MRI evaluation of right heart functions in children with mild cystic fibrosis

• Published in: Cardiology in the young Vol. 33; no. 10; pp. 1828 - 1833
• Main Authors: Temur, Hafize Otcu, Alkan, Alpay, Yozgat, Can Yilmaz, Cakir, Erkan, Yazan, Hakan, Yabul, Fatma Celik, Cesme, Dilek Hacer, Yozgat, Yilmaz
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2023
• Subjects: Age; Anatomy; Anatomy & physiology; Arteries; Blood pressure; Cardiac output; Children; Cor pulmonale; Cystic fibrosis; Disease; General Cardiology; Heart; Heart function; Hemodynamics; Hypertension; Hypertrophy; Lungs; Magnetic resonance imaging; Morphology; Original Article; Patients; Pediatrics; Physiology; Pulmonary arteries; Pulmonary artery; Pulmonary hypertension; Spirometry; Systolic pressure; Veins & arteries; Velocity; Ventricle; Germany; Cystic fibrosis; right heart functions; MRI; cor triatrium
• ISSN: 1047-9511; 1467-1107
• DOI: 10.1017/S1047951122003249

Abstract Background: This study aimed to assess the ventricular anatomy, function of the right ventricle, and the haemodynamic findings of pulmonary artery in children with cystic fibrosis using cardiac MRI. Patients: This prospective study consisted of 32 children with mild cystic fibrosis and 30 age-matched healthy control participants. Methods: Cardiac MRI was used to assess right ventricular volumes, anatomy, and function and to assessment of haemodynamic findings of pulmonary artery in the control and study groups. Haemodynamic findings of pulmonary arteries were determined using pulmonary arteries peak velocity (cm/s), and pulmonary arteries time-to-peak velocity (ms) and pulmonary artery systolic pressure. All data of children with mild cystic fibrosis were compared with those of 30 age-matched healthy control group participants. Results: Our patients and their age-matched controls were aged from 6 to 17 years and from 7 to 15 years, respectively. We found that ejection fraction (%), cardiac output (L/ml), cardiac output (L/ml/m 2 ), and systolic volume (ml/m 2 ) were significantly lower in children with cystic fibrosis (p < 0.01). Right ventricular anterior wall thickness (mm) was significantly higher in children with cystic fibrosis (p = 0.01). No significant difference was observed between the haemodynamic parameters of pulmonary artery in the patient group. Conclusion: In our study, cardiac MRI was used to investigate whether the right ventricle was affected functionally and anatomically in children with mild cystic fibrosis. We detected a significant decrease in right ventricular systolic functions and notable alterations in the right ventricular geometry of children with mild cystic fibrosis. These alterations usually manifest themselves as hypertrophy of the right ventricle. Our study’s results demonstrate no relationship between the development of pulmonary hypertension in mild cystic fibrosis children.