Cardiotoxicity related to cancer therapy

Because of recent advances in treatment of childhood cancer, there are increasing numbers of children who have survived cancer. Their future lives are complicated by late sequelae of the disease and treatment. Cardiovascular late effects are usually correlated with cardiotoxic treatment. Other late...

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Bibliographic Details
Published inProgress in pediatric cardiology Vol. 8; no. 3; pp. 145 - 155
Main Authors Hinkle, A.S, Truesdell, S.C, Proukou, C.B, Constine, L.S
Format Journal Article
LanguageEnglish
Published Elsevier Ireland Ltd 1998
Subjects
Growth hormone deficiency
Hyperthyroidism
Hypothyroidism
Neurocognitive defects
Ovarian failure
Renal dysfunction
Neurocognitive defects
Ovarian failure
Hypothyroidism
Hyperthyroidism
Growth hormone deficiency
Renal dysfunction
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Summary:Because of recent advances in treatment of childhood cancer, there are increasing numbers of children who have survived cancer. Their future lives are complicated by late sequelae of the disease and treatment. Cardiovascular late effects are usually correlated with cardiotoxic treatment. Other late effects, however, affect organ systems which may have an impact on a patient's cardiovascular status. Of particular interest are the cardiovascular effects of thyroid dysfunction (either hypothyroidism or hyperthyroidism), growth hormone deficiency, obesity, ovarian failure, pulmonary disease and renal dysfunction. In addition, psychosocial issues, such as risk-taking behavior and neurocognitive abnormalities requiring pharmacotherapy, present further cardiovascular concerns. This review discusses some of the more common non-cardiac sequelae of treatment of childhood cancer which may effect cardiac function. Knowledge of these late effects and their cardiac impact is essential as we attempt to lessen associated morbidity and mortality.
ISSN:1058-9813
1558-1519
DOI:10.1016/S1058-9813(98)00010-1