Galectin-9 expression predicts poor prognosis in hepatitis B virus-associated hepatocellular carcinoma

The aim of this study was to explore the expression of Galectin-9 in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), evaluate its clinicopathological significance, and investigate whether Galecin-9 expression has prognostic value in HBV-associated HCC. Immunohistochemistry stainin...

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Published inAging (Albany, NY.) Vol. 14; no. 4; pp. 1879 - 1890
Main Authors Jiao, Jianhua, Jiao, Dian, Yang, Fa, Zhang, Jingliang, Li, Yu, Han, Donghui, Zhang, Keying, Wang, Yingmei, Zhang, Rui, Yang, An-Gang, Wang, Anhui, Wen, Weihong, Qin, Weijun
Format Journal Article
LanguageEnglish
Published United States Impact Journals 24.02.2022
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Summary:The aim of this study was to explore the expression of Galectin-9 in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), evaluate its clinicopathological significance, and investigate whether Galecin-9 expression has prognostic value in HBV-associated HCC. Immunohistochemistry staining was performed to examine the expression of Galectin-9 in paraffin-embedded tissues from 140 cases of HBV-associated HCC specimens. The association between Gal-9 expression, clinicopathological features and prognosis was analyzed by Kaplan-Meier method, log-rank test and Cox regression analysis. Dual immunofluorescence (IF) staining was performed to identify the cell types that have positive Gal-9 expression. Among the 140 cases of HBV-associated HCC, 39 (27.9%) cases showed high Gal-9 expression (score≥6), 21 (15%) cases showed moderate Gal-9 expression (6>score≥3), 33 (23.6%) cases showed weak Gal-9 expression (3>score>0), and 47 (33.6%) cases had no detectable Gal-9 expression (score=0). Positive Gal-9 expression (score>0) was associated with lymph node metastasis ( =0.029), Ki-67 proliferation index ( =0.009) and poor prognosis. Univariate and multivariate analyses showed that Gal-9 expression could be used as an independent prognostic marker for HBV-associated HCC. Dual IF staining indicated that Gal-9 was mainly expressed in CD68 CD163 Kupffer cells (KCs) in HBV-associated HCC. Gal-9 was specifically expressed in certain HBV-associated HCC. Positive Gal-9 expression was significantly associated with poor prognosis, and Gal-9 could be used as a prognostic marker in HBV-associated HCC. Specific expression of Gal-9 on KCs indicated it may have immunosuppressive function in HBV-associated HCC.
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ISSN:1945-4589
1945-4589
DOI:10.18632/aging.203909