Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci

The growing threat of proliferation of biofilm-forming hospital strains of coagulase-negative staphylococci resistant to antibiotics determines the need for an urgent search for new effective antibacterial compounds, as well as the development of methods for the combined use of traditional and alter...

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Bibliographic Details
Published inАнтибиотики и Химиотерапия Vol. 65; no. 5-6; pp. 11 - 18
Main Authors L. I. Kononova, I. A. Pyankov, A. A. Smolyak, Yu. V. Shklyaev, V. P. Korobov
Format Journal Article
LanguageRussian
Published LLC "Publishing House OKI" 26.08.2020
Subjects
adhesion
biofilms
disinfectants
hominin
isoquinoline
minimal biofilm inhibitory concentration
staphylococci
synergism
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Summary:The growing threat of proliferation of biofilm-forming hospital strains of coagulase-negative staphylococci resistant to antibiotics determines the need for an urgent search for new effective antibacterial compounds, as well as the development of methods for the combined use of traditional and alternative antibiotics. The article presents the results of a study of the combined effect of the drug «SA» — a new synthetic derivative of the alkaloid isoquinoline and a low-molecular-weight cationic peptide of the lantibiotic family hominin, which inhibits the development of bacterial biofilms of the clinical strain of Staphylococcus haemolyticus and its vancomycin-resistant isolates. It was found that combinations of these compounds have a synergistic effect that suppresses the formation of biofilms of both studied strains of staphylococci at reduced concentrations of these antibacterial compounds.
ISSN:0235-2990
DOI:10.37489/0235-2990-2020-65-5-6-11-18