Sawtehtetronenin from Goniothalamus sawtehii and its Cytotoxicity

A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetrone...

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Published inNatural product communications Vol. 9; no. 12; pp. 1769 - 1771
Main Authors Thiplueang, Chiarpha, Punyanitya, Sittiporn, Banjerdpongchai, Ratana, Wudtiwai, Benjawan, Udomputtimekakul, Phansuang, Buayairaksa, Mongkol, Nuntasaen, Narong, Pompimon, Wilart
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.12.2014
Subjects
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Goniothalamus - chemistry
Hep G2 Cells
Humans
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Plant Leaves - chemistry
Cytotoxicity
Annonaceae
Acetogenin
Cancer cells
Goniothalamus sawtehii
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Summary:A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3+11.9 μM and 108.1+1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1400901228