Preoperative localization of water clear cell giant parathyroid adenoma: A case report

Primary hyperparathyroidism commonly results from a solitary parathyroid adenoma. A water clear cell parathyroid adenoma represents a rare histological variant. This report presents the challenges of preoperative detection of a giant parathyroid adenoma, which was of the water clear cell variant. A...

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Published inRadiology case reports Vol. 19; no. 6; pp. 2492 - 2497
Main Authors Gossili, Farid, Gauduseviciene, Simona, Erentaite, Daiva, Iversen, Peter, Almasi, Charlotte E.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.06.2024
Elsevier
Subjects
[11C]C-Methionine PET/CT
Giant parathyroid adenoma
Water clear cell
PTH
MRI
H&E
SPECT
CK7
4D-CT
Giant parathyroid adenoma
Water clear cell
PET/CT
PPV
PHPT
GPA
EANM
PTA
[11C]C-Methionine PET/CT
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Summary:Primary hyperparathyroidism commonly results from a solitary parathyroid adenoma. A water clear cell parathyroid adenoma represents a rare histological variant. This report presents the challenges of preoperative detection of a giant parathyroid adenoma, which was of the water clear cell variant. A case of severe hypercalcemia in a patient without clinical symptoms and equivocal findings on standard imaging modalities, in which the use of [11C]C-Methionine PET/CT facilitated the preoperative detection of a giant parathyroid adenoma. Histopathological examination confirmed the diagnosis of a water clear cell giant parathyroid adenoma following surgical excision. These findings highlight the significance of advanced imaging techniques in the detection and management of a rare form of parathyroid adenoma.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2024.03.026