Cartilage Metabolic Status for the Radiographic Medial Knee Joint Space Narrowing in Men in Early Forties Without Knee Pain

• Published in: Juntendo Iji Zasshi = Juntendo Medical Journal Vol. 62; no. Suppl.1; p. 171
• Main Authors: LIU, LIZU, KINOSHITA, MAYUKO, ISHIJIMA, MUNEAKI, KANEKO, HARUKA, SADATSUKI, RYO, HADA, SHINNOSUKE, SHIOZAWA, JUN, ARITA, HITOSHI, SAITA, YOSHITOMO, TAKAZAWA, YUJI, IKEDA, HIROSHI, KANEKO, KAZUO
• Format: Journal Article
• Language: English
• Published: The Juntendo Medical Society 2016
• Subjects: collagen type II cleavage; knee joint space width; osteoarthritis; type II C-propeptide; type II collagen C-telopeptide
• ISSN: 2187-9737; 2188-2126
• DOI: 10.14789/jmj.62.s171

Objective: To investigate the cartilage metabolic status which can predict radiographic medial knee joint space narrowing (mJSN) in men in early forties without knee pain.Design: In this prospective study, forty seven healthy male volunteers (41.6 y on average) who didn’t have knee pain and experience any traumatic episodes for the knee joints were enrolled.Intervention: A radiograph of both knee were taken and the serum levels of pro-collagen type II C-propeptide (sPIICP) and collagen type II cleavage (C2C) and urinary level of cross-inked type II collagen C-telopeptide (uCTX-II) were measured at the time of study entry. Radiological progression of the knee OA is defined as mJSN greater than 0.3 mm in either of the knees during 3-years of follow up.Results: The fourteen of 47 subjects were involved in the progression (P) group, while the remaining thirty-three subjects were involved in the non-progression (NP) group. No significant differences of the sPIICP, sC2C and uCTX-II in P group were observed in comparison to those in NP group at baseline. The sC2C/sPIICP of P group, but not uCTX-II/sPIICP, was significantly decreased in comparison to those of NP group (p<0.05). The age- and BMI- adjusted risk for the progression after 3-years of follow up in the lower tertile (T1) of the sC2C/sPIICP at baseline was significantly higher than that in the higher tertile (T3) [Odds ratio: 9.8 (95%CI: 1.4-67.4)].Conclusion: In a three year prospective study, the lower sC2C/sPIICP was the risk factor for the radiographic mJSN in men in early forties without knee pain.