Thalidomide sensory neurotoxicity: a clinical and neurophysiologic study

The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this...

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Bibliographic Details
Published inNeurology Vol. 62; no. 12; p. 2291
Main Authors Cavaletti, G, Beronio, A, Reni, L, Ghiglione, E, Schenone, A, Briani, C, Zara, G, Cocito, D, Isoardo, G, Ciaramitaro, P, Plasmati, R, Pastorelli, F, Frigo, M, Piatti, M, Carpo, M
Format Journal Article
LanguageEnglish
Published United States 22.06.2004
Subjects
Adult
Aged
Dose-Response Relationship, Drug
Female
Humans
Male
Middle Aged
Neurotoxicity Syndromes - diagnosis
Neurotoxicity Syndromes - etiology
Thalidomide - administration & dosage
Thalidomide - poisoning
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Summary:The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.
ISSN:1526-632X
DOI:10.1212/WNL.62.12.2291