Amoxycillin causes an enhanced uptake of metronidazole in Actinobacillus actinomycetemcomitans: a mechanism of synergy

We investigated the influence of sub-inhibitory concentrations amoxycillin on metronidazole uptake of the metronidazole-susceptible facultative microorganism Actinobacillus actinomycetemcomitans. The rate of metronidazole uptake by bacterial cells simultaneously incubated with amoxycillin was higher...

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Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 34; no. 6; p. 1047
Main Authors Pavicić, M J, van Winkelhoff, A J, Pavicić-Temming, Y A, de Graaff, J
Format Journal Article
LanguageEnglish
Published England 01.12.1994
Subjects
Aggregatibacter actinomycetemcomitans - metabolism
Amoxicillin - pharmacology
Drug Synergism
Metronidazole - pharmacokinetics
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Summary:We investigated the influence of sub-inhibitory concentrations amoxycillin on metronidazole uptake of the metronidazole-susceptible facultative microorganism Actinobacillus actinomycetemcomitans. The rate of metronidazole uptake by bacterial cells simultaneously incubated with amoxycillin was higher than uptake in cells incubated with metronidazole alone. This phenomenon may explain the recently reported in-vitro synergic interaction between metronidazole and amoxycillin against A. actinomycetemcomitans.
ISSN:0305-7453
DOI:10.1093/jac/34.6.1047