Ileo-caecal resection induced pancreatic growth in rats

• Published in: Peptides (New York, N.Y. : 1980) Vol. 6; no. 2; pp. 211 - 215
• Main Authors: Baba, N., Chowdhury, P., Inoue, K., Ami, M., Rayford, P.L.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1985; Elsevier Science
• Subjects: Aging; Animals; Biological and medical sciences; Body Weight; CCK; Cecum - physiology; Cecum - surgery; Cholecystokinin - blood; Exocrine pancreas; Fundamental and applied biological sciences. Psychology; Gastrin; Gastrins - blood; Ileo-caecal resection; Ileum - physiology; Ileum - surgery; Inhibitory factor; Male; Pancreas - growth & development; Pancreas - physiology; Pancreatic growth; Rats; Rats, Inbred Strains; Vertebrates: digestive system; Pancreatic growth; Inhibitory factor; Ileo-caecal resection; CCK; Gastrin; Vertebrata; Mammalia; Resection anastomosis; Resection; Rat; Digestive system; Growth; Rodentia; Peptide hormone; Ileocecal; Pancreas; Ileum
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/0196-9781(85)90042-7

The effect of ileo-caecal resection on pancreatic growth was studied in rats four weeks after the operation. The results were compared with an identical control group who had undergone laparotomy alone. Pancreatic wet weight in ileo-caecal resectioned rats was 1.4 times greater than that found in control rats. Protein, DNA, RNA contents in the pancreas, pancreatic wet weight per 100 μg DNA and RNA/DNA ratio were also found significantly elevated in experimental group as opposed to the control group. Basal plasma levels of cholecystokinin (CCK) and gastrin were measured to delineate the influence of hormonal response on the pancreatic growth in ileo-caecal resected rats and were found not significantly increased after ileo-caecal resection. The data suggest that the enlargement of pancreas in ileo-caecal resected rats may be due to hyperplasia and hypertrophy of pancreatic cells; alternatively, the pancreatic growth may have been influenced by the bile acid deficiency and the reduction or release of an inhibitory factor present in the ileum of rats.