Unconventional effects of estrogen uncovered

The nigrostriatal dopamine system shows marked gender differences that, in many cases, can be attributable to estrogen. However, the virtual absence of conventional estrogen receptors within the nigrostriatal dopamine system has made it difficult to understand how estrogen can function within this s...

Full description

Saved in:
Bibliographic Details
Published inTrends in pharmacological sciences (Regular ed.) Vol. 26; no. 10; pp. 485 - 487
Main Author Dluzen, Dean E
Format Journal Article
LanguageEnglish
Published England 01.10.2005
Subjects
Animals
Corpus Striatum - metabolism
Corpus Striatum - physiology
Dopamine - metabolism
Estrogens - physiology
GTP-Binding Proteins - metabolism
Humans
Receptors, Dopamine D2 - metabolism
Signal Transduction - physiology
Substantia Nigra - metabolism
Substantia Nigra - physiology
Online AccessGet full text

Cover

More Information
Summary:The nigrostriatal dopamine system shows marked gender differences that, in many cases, can be attributable to estrogen. However, the virtual absence of conventional estrogen receptors within the nigrostriatal dopamine system has made it difficult to understand how estrogen can function within this system. Recent findings have helped to uncover how estrogen can affect a discrete function of striatal dopamine-containing neurons--transporter activity--in a manner similar to that achieved through alterations in dopamine D(2) receptors and their associated G protein. These findings suggest that the effects of estrogen on dopamine transporter function could result from a signal transduction interaction involving D(2) receptor-G protein coupling.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0165-6147
DOI:10.1016/j.tips.2005.08.001