Plasma fibronectin in normolipidaemic and hyperlipidaemic uraemic patients treated with haemodialysis

• Published in: Clinica chimica acta Vol. 168; no. 3; pp. 281 - 286
• Main Authors: De Giorgio, Lamberto A., Maffucci, Giorgio, Toscano, Giuseppe, Gironi, Alfredo, Vignoli, Stefano, Seghieri, Giuseppe
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 15.10.1987; Elsevier
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Apoproteins A and B; Biological and medical sciences; Cholesterol - blood; Chronic renal failure; Emergency and intensive care: renal failure. Dialysis management; Endothelial damage; Female; Fibronectins - blood; Hemodialysis; Humans; Hyperlipidemia; Hyperlipidemias - blood; Hyperlipidemias - complications; Intensive care medicine; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Lipoproteins - blood; Male; Medical sciences; Middle Aged; Plasma fibronectin; Reference Values; Renal Dialysis; Endothelial damage; Chronic renal failure; Hemodialysis; Hyperlipidemia; Apoproteins A and B; Plasma fibronectin; Extrarenal dialysis; Urinary system disease; Renal failure; Glycoproteins; Hyperlipemia; Fibronectin; Resuscitation
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/0009-8981(87)90003-9

Plasma fibronectin (PF) concentrations, were investigated in normolipidaemic and hyperlipidaemic (type IV) patients with chronic renal failure treated with hemodialysis ( n = 29) and in controls ( n = 34). Mean PF was significantly reduced in both subsets of dialysed patients. Among the hemodialysed patients the presence of hyperlipidaemia did not modify PF levels, which resulted, on the contrary, significantly higher in hyperlipidaemic controls as compared with the normolipidaemic group. In controls, according to a multivariate analysis model, PF was directly related with age and inversely with HDL-cholesterol. In the hemodialysed patients total cholesterol was the unique significant PF related variate, being this group, therefore, characterized by the lack of any inverse relation between PF and HDL-cholesterol. Finally, no PF modifications were observed in hemodialyzed patients affected by arterial hypertension or clinically evident atherosclerotic lesions.