Melamine-formaldehyde resin supported H + -catalyzed three-component synthesis of 1,8-dioxo-decahydroacridine derivatives in water and under solvent-free conditions

Abstract A convenient and practical synthesis of 1,8-dioxo-decahydroacridine derivatives using various aldehydes, 5,5-dimethyl-1,3-cyclohexanedione and thiourea in water, was successfully carried out in the presence of melamine-formaldehyde resin supported H + (MFRH) as a catalyst. Under solvent-fre...

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Published inHeterocyclic communications Vol. 19; no. 1; pp. 57 - 63
Main Authors Rezaei, Ramin, Khalifeh, Reza, Rajabzadeh, Maryam, Dorosty, Liela, Doroodmand, Mohammad Mahdi
Format Journal Article
LanguageEnglish
Published Berlin Walter de Gruyter GmbH 01.03.2013
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Summary:Abstract A convenient and practical synthesis of 1,8-dioxo-decahydroacridine derivatives using various aldehydes, 5,5-dimethyl-1,3-cyclohexanedione and thiourea in water, was successfully carried out in the presence of melamine-formaldehyde resin supported H + (MFRH) as a catalyst. Under solvent-free conditions, rapid and efficient synthesis of 1,8-dioxo-decahydroacridine and N -substituted 1,8-dioxo-decahydroacridine derivatives could also be achieved using ammonium acetate and aromatic amines as the nitrogen source.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2012-0053