Mutagenic activity of promutagens in plants: indirect evidence of their activation

This review summarizes data concerning mutagenic activity of promutagens in various plant in vivo assays. These data are compared with the present knowledge about the metabolism of xenobiotics and activation of promutagens in plants obtained by biochemical studies and by the separation of the activa...

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Bibliographic Details
Published inMutation research Vol. 197; no. 2; p. 221
Main Authors Velemínský, J, Gichner, T
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1988
Subjects
Aflatoxins - metabolism
Amines - metabolism
Animals
Biotransformation
Microsomes, Liver - metabolism
Mixed Function Oxygenases - metabolism
Mutagenicity Tests - methods
Mutagens - biosynthesis
Mutagens - classification
Mutagens - pharmacology
Nitrosamines - metabolism
Oxidation-Reduction
Pesticides - metabolism
Plant Proteins - metabolism
Plants - drug effects
Plants - metabolism
Polycyclic Compounds - metabolism
Species Specificity
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Summary:This review summarizes data concerning mutagenic activity of promutagens in various plant in vivo assays. These data are compared with the present knowledge about the metabolism of xenobiotics and activation of promutagens in plants obtained by biochemical studies and by the separation of the activation process from the genetic endpoints assayed for the mutagenicity. The article documents a differential response of plant species in the endogenous transforming of various classes of promutagens into mutagens. Attention is devoted to the following types of promutagens: nitrosamines, polycyclic aromatic hydrocarbons and aromatic amines, aflatoxins, pyrrolizidine alkaloids, diallate, styrene, vinylchloride, ethanol, cycasin, nitrofurans, sodium azide, s-triazine herbicides, 1,2-dibromoethane and maleic hydrazide.
ISSN:0027-5107
DOI:10.1016/0027-5107(88)90095-4