Effects of naloxone on seizure latencies of black (a/a) Mongolian gerbils (Meriones unguiculatus)

The effects of the opiate antagonist, naloxone, on seizure tendencies of the black or nonagouti line of Mongolian gerbils (Meriones unguiculatus) carrying the a/a coat color allele was investigated. The animals were tested under the following conditions: mock infection; 0.9% NaCl injection; and nalo...

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Bibliographic Details
Published inBehavior genetics Vol. 21; no. 5; p. 487
Main Authors Wong, R, Gray-Allan, P
Format Journal Article
LanguageEnglish
Published United States 01.09.1991
Subjects
Animals
beta-Endorphin - genetics
beta-Endorphin - physiology
Brain - drug effects
Dose-Response Relationship, Drug
Electroencephalography - drug effects
Gerbillinae - genetics
Naloxone - pharmacology
Reaction Time - drug effects
Reaction Time - genetics
Reaction Time - physiology
Seizures - genetics
Seizures - physiopathology
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Summary:The effects of the opiate antagonist, naloxone, on seizure tendencies of the black or nonagouti line of Mongolian gerbils (Meriones unguiculatus) carrying the a/a coat color allele was investigated. The animals were tested under the following conditions: mock infection; 0.9% NaCl injection; and naloxone at doses of 1, 2, 5, and 10 mg/kg body weight. The results indicated that when naloxone was at doses of 2 mg/kg body weight and higher, there was an increase in the animals' seizure latencies relative to that manifested under the basal condition.
ISSN:0001-8244
DOI:10.1007/BF01066726