Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes

• Published in: Cell Vol. 28; no. 3; pp. 471 - 476
• Main Authors: Artzt, Karen, Shin, Hee-Sup, Bennett, Dorothea
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 01.03.1982; Cell Press
• Subjects: Animals; Biological and medical sciences; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; Crossing Over, Genetic; Female; Fundamental and applied biological sciences. Psychology; Genes, Lethal; Genetics of eukaryotes. Biological and molecular evolution; H-2 Antigens - genetics; H-2 Antigens - immunology; Histocompatibility Testing; Male; Mice; Mice, Inbred Strains; Mutation; Polymorphism, Genetic; Recombination, Genetic; Genetic mapping; Vertebrata; Histocompatibility system; Mammalia; Mouse; Rodentia; Mutation; H-2-System
• ISSN: 0092-8674; 1097-4172
• DOI: 10.1016/0092-8674(82)90201-X

Naturally occurring t haplotypes are chromosome 17 polymorphisms that suppress genetic recombination in t/+ heterozygotes over a long distance that includes the H-2 complex. There is strong linkage disequilibrium between t haplotypes and H-2 haplotypes; over 20 independently isolated t chromosomes representing eight different complementation groups share only four H-2 haplotypes. Thus t haplotypes and their associated H-2 loci are inherited en bloc as a “supergene” complex, whose frequency is driven in wild mouse populations by their high transmission from male t heterozygotes. This phenomenon must therefore serve as an important regulator of H-2 polymorphisms. Genes within the region of recombination suppression in t haplotypes have been mapped by crossing-over that occurs readily between two different t haplo-types situated in trans, and by this means we show here that the H-2 complex occupies an anomalous position in t haplotypes, mapping proximal to the locus of tf closely flanked by t-lethal mutations.