Artificial metallonucleases

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the re...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) no. 20; p. 2540
Main Authors Mancin, Fabrizio, Scrimin, Paolo, Tecilla, Paolo, Tonellato, Umberto
Format Journal Article
LanguageEnglish
Published England 28.05.2005
Subjects
Catalysis
Deoxyribonucleases - chemical synthesis
Deoxyribonucleases - chemistry
DNA - chemistry
Hydrolysis
Ligands
Metals - chemistry
Molecular Structure
Substrate Specificity
Online AccessGet more information

Cover

More Information
Summary:The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.
ISSN:1359-7345
DOI:10.1039/b418164f