Air Pollution and Skin Diseases

• Published in: Annals of dermatology Vol. 37; no. 2; pp. 53 - 67
• Main Authors: Han, Hye Sung, Seok, Joon, Park, Kui Young
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Dermatological Association; The Korean Society for Investigative Dermatology 01.04.2025; 대한피부과학회
• Subjects: Review; 피부과학; Aryl hydrocarbon receptor; Oxidative stress; Skin diseases; Air pollutants
• ISSN: 1013-9087; 2005-3894; 2005-3894
• DOI: 10.5021/ad.24.159

Air pollution is a widespread environmental issue, with substantial global implications for human health. Recent epidemiological studies have shown that exposure to air pollution exacerbates various inflammatory skin conditions, including atopic dermatitis, psoriasis, or acne. Furthermore, air pollutants are associated with accelerated skin aging, hair loss, and skin cancer. The aim of this review is to elucidate the current understanding of the impact of air pollution on skin health, emphasizing the underlying mechanisms involved and existing therapeutic and cosmetic interventions available to prevent or mitigate these effects. A pivotal factor in the harmful effects of air pollution is the formation of reactive oxygen species and the resulting oxidative stress. The aryl hydrocarbon receptor signaling pathway also substantially contributes to mediating the effects of air pollutants on various skin conditions. Moreover, air pollutants can disrupt the skin barrier function and trigger inflammation. Consequently, antioxidant and anti-inflammatory therapies, along with treatments designed to restore the skin barrier function, have the potential to mitigate the adverse effects of air pollutants on skin health.