In vitro activity of CI-934 compared with ciprofloxacin, enoxacin, norfloxacin, and vancomycin
The in vitro activity of the quinolone CI-934 was compared with ciprofloxacin, norfloxacin, enoxacin, and vancomycin against 607 Gram-positive and -negative isolates. CI-934 inhibited 90% of the Enterobacteriaceae , Aeromonas hydrophila , and Acinetobacter spp. at 1 μg/ml. Decreased activity was obs...
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Published in | Diagnostic microbiology and infectious disease Vol. 6; no. 4; pp. 301 - 306 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.04.1987
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The in vitro activity of the quinolone CI-934 was compared with ciprofloxacin, norfloxacin, enoxacin, and vancomycin against 607 Gram-positive and -negative isolates. CI-934 inhibited 90% of the
Enterobacteriaceae
,
Aeromonas
hydrophila
, and
Acinetobacter
spp. at 1 μg/ml. Decreased activity was observed against
Pseudomonas
aeruginosa
,
Pseudomonas
maltophilia
, and other
Pseudomonas
spp. with CI-934 MIC
90 ⩾ 8
μg/ml. CI-934 activity against Gram-positive organisms exceeded vancomycin and the other quinolones. MIC
90 for
Streptococcus
faecalis
,
Listeria
monocytogenes
, and
Corynebacterium
spp. were ⩽2
μg/ml. CI-934 was equally effective against oxacillin-susceptible and -resistant staphylococci with MIC
90 of 0.5 μg/ml. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0732-8893 1879-0070 |
DOI: | 10.1016/0732-8893(87)90179-9 |