In vitro activity of CI-934 compared with ciprofloxacin, enoxacin, norfloxacin, and vancomycin

• Published in: Diagnostic microbiology and infectious disease Vol. 6; no. 4; pp. 301 - 306
• Main Authors: Floyd-Reising, Shirley A., Kelley, Susan G., Hindler, Janet A., Young, Lowell S.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.1987; Elsevier
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria - drug effects; Biological and medical sciences; Ciprofloxacin - pharmacology; Enoxacin; Fluoroquinolones; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Medical sciences; Microbial Sensitivity Tests; Naphthyridines - pharmacology; Norfloxacin - pharmacology; Pharmacology. Drug treatments; Quinolines - pharmacology; Vancomycin - pharmacology; Pseudomonadales; Drug susceptibility test; Aeromonas; Neisseriaceae; Pseudomonas; In vitro; Biological activity; Antibiotic; Minimum inhibitory concentration; Bacteria; Micrococcales; Pseudomonadaceae; Vibrionaceae; Acinetobacter; Antibacterial agent; Comparative study; Enterobacteriaceae
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/0732-8893(87)90179-9

The in vitro activity of the quinolone CI-934 was compared with ciprofloxacin, norfloxacin, enoxacin, and vancomycin against 607 Gram-positive and -negative isolates. CI-934 inhibited 90% of the Enterobacteriaceae , Aeromonas hydrophila , and Acinetobacter spp. at 1 μg/ml. Decreased activity was observed against Pseudomonas aeruginosa , Pseudomonas maltophilia , and other Pseudomonas spp. with CI-934 MIC 90 ⩾ 8 μg/ml. CI-934 activity against Gram-positive organisms exceeded vancomycin and the other quinolones. MIC 90 for Streptococcus faecalis , Listeria monocytogenes , and Corynebacterium spp. were ⩽2 μg/ml. CI-934 was equally effective against oxacillin-susceptible and -resistant staphylococci with MIC 90 of 0.5 μg/ml.