Comparison of two oral antibiotics, roxithromycin and amoxicillin plus clavulanic acid, in lower respiratory tract infections
In a randomized, multicenter, open-label study, 490 ambulatory adult patients withu lower respiratory tract infection (LRTI) were randomized to roxithromycin (ROX) 150 mg b.i.d. orally ( n = 244) or amoxicillin plus clavunalic acid (AMX + CA) as 500 mg AMX + 125 mg CA t.i.d. orally ( n = 24). Clinic...
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Published in | Diagnostic microbiology and infectious disease Vol. 15; no. 4; pp. 85 - 89 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
New York, NY
Elsevier Inc
01.05.1992
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | In a randomized, multicenter, open-label study, 490 ambulatory adult patients withu lower respiratory tract infection (LRTI) were randomized to roxithromycin (ROX) 150 mg b.i.d. orally (
n = 244) or amoxicillin plus clavunalic acid (AMX + CA) as 500 mg AMX + 125 mg CA t.i.d. orally (
n = 24). Clinical results were analyzed in 477 patients withu acute bronchitis (79%), chronic bronchitis (CB) (14%), and pneumonia (7%). There were significantly more patients with underlying disease (cardiovascular diseases,
p = 0.045; and alcoholism ,
p<0.001, and more patients over the age of 65 years (
p=0.045 in the ROX group. Overall clinical efficacy was similar in both groups: 88% (206:235) in the ROX group and 85% (205:242) in the AMX + CA group. Side effects were reported in 67 cases (28%0 in the AMX + CA group and in 21 cases (9%) in the ROX group (
p><0.00010, causing withdrawal in 21 and three cases, respectively (
p<0.001. Thus despite being administered to a significantly older and more ill group of patients with LRTI, roxithromycin was as effective as amoxicillin plus clavunalic acid and better tolerated. |
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ISSN: | 0732-8893 1879-0070 |
DOI: | 10.1016/0732-8893(92)90133-E |