External Quality Assessment of Bone Metabolism Marker Assays. Initial Experiences in a UK NEQAS Programme

• Published in: Clinical chemistry and laboratory medicine Vol. 38; no. 11; pp. 1121 - 1124
• Main Authors: Whitham, Karen Marie, Milford-Ward, Anthony
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Berlin Walter de Gruyter 12.11.2000; New York, NY
• Subjects: Alkaline Phosphatase - blood; Biological and medical sciences; Biomarkers; Bone and Bones - enzymology; Bone and Bones - metabolism; Collagen - blood; Collagen Type I; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Osteoarticular system. Muscles; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Peptides - blood; Quality Control; Reference Values; United Kingdom; Europe; Human; Alkaline phosphatase; Biochemical analysis; Procollagen; C terminal peptide; Enzyme; Diseases of the osteoarticular system; Phosphoric monoester hydrolases; Biological indicator; Esterases; Laboratory; Metabolism; N terminal peptide; Accuracy; Clinical biology; Quality control; Analytical method; External; Deoxypyridinoline; Hydrolases; Bone; Comparative study
• ISSN: 1434-6621; 1437-4331
• DOI: 10.1515/CCLM.2000.168

This paper reports on a pilot external quality assessment scheme for bone markers including serum bone alkaline phosphatase and procollagen 1-carboxy terminal propeptide together with urine deoxypyridinoline, N- and C-telopeptides. The data shows poor numerical agreement between commercial assays, between-laboratory imprecision that could be improved, and the need for international standardisation of assays.