DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications

We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic-superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microo...

Full description

Saved in:
Bibliographic Details
Published inLab on a chip Vol. 12; no. 24; pp. 5218 - 5224
Main Authors Ueda, Erica, Geyer, Florian L, Nedashkivska, Victoria, Levkin, Pavel A
Format Journal Article
LanguageEnglish
Published England 21.12.2012
Subjects
Arrays
Cell Line, Tumor
Cell Separation - instrumentation
Cell Survival
Cellular Microenvironment
Chips
Doxorubicin - pharmacology
Droplets
Drug Screening Assays, Antitumor
Humans
Hydrogels
Hydrogels - chemistry
Liquids
Microfluidic Analytical Techniques - methods
Microorganisms
Screening
Three dimensional
Online AccessGet full text

Cover

More Information
Summary:We describe a one-step method for creating thousands of isolated pico- to microliter-sized droplets with defined geometry and volume. Arrays of droplets are instantly formed as liquid moves along a superhydrophilic-superhydrophobic patterned surface. Bioactive molecules, nonadherent cells, or microorganisms can be trapped in the fully isolated microdroplets for high-throughput screening, or in hydrogel micropads for screening in 3D microenvironments.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1473-0197
1473-0189
DOI:10.1039/c2lc40921f