Cardiac involvement in non-specific aorto-arteritis

• Published in: International journal of cardiology Vol. 34; no. 3; pp. 289 - 295
• Main Authors: Panja, Manotosh, Kar, A.K., Dutta, A.L., Chhetri, M., Kumar, S., Panja, S.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.03.1992; Elsevier Science
• Subjects: Adolescent; Adult; Aortic disease; Arterial disease; Biological and medical sciences; Cardiac Catheterization; Child; Child, Preschool; Coronary Angiography; Electrocardiography; Female; Heart Diseases - etiology; Heart Diseases - pathology; Heart Diseases - physiopathology; Hemodynamics; Humans; Male; Medical sciences; Retrospective Studies; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Takayasu Arteritis - complications; Takayasu Arteritis - diagnosis; Takayasu Arteritis - pathology; Takayasu Arteritis - physiopathology; Arterial disease; Aortic disease; Heart; Sonography; Pathology; Radiodiagnosis; Systemic disease; Coronary artery; Cardiovascular disease; Complication; Exploration; Pulmonary artery; Takayashu arteritis
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/0167-5273(92)90027-Z

Cardiac involvement in 75 cases (mean age 21.1 ± 6 years) with non-specific aorto-arteritis was studied. Detailed clinical examination, echocardiography and cardiac catheterization, including angiography, were done in all the cases, as was coronary angiography. Features of cardiac failure like sinus tachycardia, cardiomegaly, left ventricular third heart sound gallop and pulmonary congestion were detected in 27 cases with reduction of left ventricular ejection fraction (25–48%). Systemic hypertension was seen in 60 cases. Central aortic pressure, left ventricular systolic pressure and left ventricular end-diastolic pressure were increased in 66 cases. Pulmonary hypertension and increased pulmonary vascular resistance were detected in 6 cases. Aortic and mitral regurgitation were seen in 15 and 12 cases, respectively. Three patients had features of dilated cardiomyopathy such as generalized cardiomegaly, systemic and pulmonary congestion but without any cardiac murmurs and with normal central aortic pressure. The coronary angiogram revealed obstruction of the left anterior descending artery in 3 cases and right coronary artery obstruction in another 3 cases. Histopathological studies revealed non-specific inflammatory changes with fibrosis in cardiac musculature and the great vessels.