Dimerization approach to (+)-asperazine A

• Published in: Chem Vol. 9; no. 2; pp. 258 - 259
• Main Authors: Zhang, Yiwei, Ting, Chi P.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 09.02.2023
• ISSN: 2451-9294; 2451-9294
• DOI: 10.1016/j.chempr.2023.01.015

Tryptophan-linked dimeric diketopiperazine alkaloids possess great molecular diversity and bioactivity. In this issue of Chem, Jiang and co-workers report an oxidative approach to those alkaloids containing an unsymmetrical C3-N1′ linkage. In their concise synthesis of (+)-asperazine, they successfully dimerized a designer tryptophan-alternative building block through the sustained release of electrophilic iodine. Tryptophan-linked dimeric diketopiperazine alkaloids possess great molecular diversity and bioactivity. In this issue of Chem, Jiang and co-workers report an oxidative approach to those alkaloids containing an unsymmetrical C3-N1′ linkage. In their concise synthesis of (+)-asperazine, they successfully dimerized a designer tryptophan-alternative building block through the sustained release of electrophilic iodine.