Activity of redox-regulatory systems in the tumor and surrounding tissues in various histological types of tumors

• Published in: Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 10; no. 4; pp. 335 - 340
• Main Authors: Surikova, E. I., Goroshinskaja, I. A., Nerodo, G. A., Frantsiyants, E. M., Malejko, M. L., Shalashnaja, E. V., Kachesova, P. S., Nemashkalova, L. A., Leonova, A. V.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.10.2016; Springer Nature B.V
• Subjects: Antioxidants; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; Enzymes; Gastric cancer; Histology; Medicinal Chemistry; redox balance; glutathione-dependent system; gastric adenocarcinoma; antioxidant enzymes; vulvar squamous cell carcinoma; the environment of the tumor
• ISSN: 1990-7508; 1990-7516
• DOI: 10.1134/S1990750816040089

According to modern concepts, a malignant tumor is a complex dynamic system possessing numerous links with both the immediate environment and remote non-malignant tissues and organs. Changes in their redox balance can result in disruption of the normal tissue control. The aim of our study was to compare activity of enzymes influencing the redox state in the tumor tissue, peritumoral area, and nonmalignant tissues (taken by resection line) at various histological tumor variants. We found similar close level of reduced glutathione in the tissues of gastric adenocarcinoma and vulvar squamous cell carcinoma; however, dynamics of this parameter in the tumor surrounding tissues was different. In contrast to gastric adenocarcinoma, vulvar squamous cell carcinoma was characterized by a significant increase in glutathione content in the tumor tissue and increased activity of all investigated enzymes of the glutathione system in the tumor tissue and its peritumoral area as compared with the surrounding non-malignant tissue. These results underlie existence of clear differences in the functioning of the redox regulatory systems in the tumor and surrounding tissues of various histological origin and localization; these differences may be possibly attributed to different mechanisms involved in maintenance of the redox balance in the originally non-malignant tissues.