Relation of MPO, MnSOD, NQO1 gene variants in endometrial carcinoma in the line of PCR-RFLP methods

Reactive oxygen species (ROS) have been shown to be responsible for inducing DNA damage leading to mutagenesis, carcinogenesis, and cell death if the capacity of the protective antioxidant system is impaired. Endometrial carcinoma is the primary cancer type in the female genital system. The enhanced...

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Published inCellular and Molecular Biology Vol. 64; no. 4; pp. 78 - 82
Main Authors Bulgurcuoglu Kuran, Sibel, Iplik, Elif Sinem, Cakmakoglu, Bedia, Timirci Kahraman, Ozlem, Iyibozkurt, Ahmet Cem, Koc, Arzu, Ergen, Arzu, Gulec Yilmaz, Seda, Isbir, Turgay
Format Journal Article
LanguageEnglish
Published France 31.03.2018
Subjects
NQO1
Endometrial carcinoma
MPO
MnSOD
Polymorphism
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Summary:Reactive oxygen species (ROS) have been shown to be responsible for inducing DNA damage leading to mutagenesis, carcinogenesis, and cell death if the capacity of the protective antioxidant system is impaired. Endometrial carcinoma is the primary cancer type in the female genital system. The enhanced cell lipid peroxidation and impaired antioxidant enzyme activities observed in patients with endometrial cancer indicate the potential for oxidative injury to cells and cell membranes in such patients. The aim of the study was to investigate the possible association between gene variants of superoxide dismutase (SOD), myeloperoxidase (MPO), and NADPH quinone oxido reductase (NQO1), and their possible role in endometrial cancer in Turkish patients. According to results, MPO G+ genotype and AG genotype were significantly increased in patients compared with controls (P<0.001). We suggest that the MPO polymorphism might be a risk for endometrial cancer.
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ISSN:0145-5680
1165-158X
DOI:10.14715/cmb/2018.64.4.13