Red-cell glucose-6-phosphate dehydrogenase of “brown-howler” monkeys ( Alouatta fusca)

• Published in: Journal of human evolution Vol. 9; no. 7; pp. 565 - 571
• Main Authors: Itskan-Forshaid, S.B., Maia, J.C.C., Nóbrega, F.G., Saldanha, P.H.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.01.1980
• Subjects: G6PD; physico-chemical properties; “brown-howler” monkeys; physico-chemical properties; G6PD; “brown-howler” monkeys
• ISSN: 0047-2484; 1095-8606
• DOI: 10.1016/0047-2484(80)90064-0

Physico-chemical properties of erythrocyte glucose-6-phosphate dehydrogenase including erythrocyte G6PD activity, Michaelis constants, K mG6P and NADP, pH optimum, thermostability and molecular weight were investigated in “brown-howler” monkeys and then compared with the values of human G6PD B(+). The values of Michaelis constants (K mG6P and NADP) pH optimum were the same as the values of human G6PD B(+). The human G6PD has a dimeric form in the assay conditions employed in the present study, monkey enzyme showing great similariy with human one. Otherwise, the thermostability differed from the human G6PD. The simian enzymatic activity was about four times higher than the human G6PD. A comparison of physico-chemical properties of glucose-6-phosphate dehydrogenase among primates is also presented.