Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d...

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Bibliographic Details
Published inNature (London) Vol. 293; no. 5831; p. 370
Main Authors Jenkins, N A, Copeland, N G, Taylor, B A, Lee, B K
Format Journal Article
LanguageEnglish
Published England 01.10.1981
Subjects
Animals
Base Sequence
Cell Transformation, Viral
Chromosome Mapping
DNA, Viral - genetics
Genetic Linkage
Leukemia Virus, Murine - genetics
Mice
Mice, Inbred DBA - genetics
Mice, Mutant Strains - genetics
Recombination, Genetic
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Summary:The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.
ISSN:0028-0836
DOI:10.1038/293370a0