Lower serum levels of alpha tocopherol and lycopene is associated with higher pain and physical disability in subjects with primary knee osteoarthritis: A case-control study

• Published in: International journal for vitamin and nutrition research p. 1
• Main Authors: Eftekharsadat, Bina, Aghamohammadi, Dawood, Dolatkhah, Neda, Hashemian, Maryam, Salami, Halale
• Format: Journal Article
• Language: English
• Published: Switzerland 01.06.2021
• Subjects: lycopene; Osteoarthritis; α-tocopherol
• ISSN: 0300-9831
• DOI: 10.1024/0300-9831/a000635

: We aimed to determine dietary intake and serum concentration of α-tocopherol and lycopene in subjects with knee osteoarthritis (KOA) in relation to pain intensity and functional status and comparing them with healthy controls. : This case-control study was conducted among 35 patients with primary KOA and 35 matched healthy subjects selected using convenience sampling method. Dietary intakes of alpha-tocopherol and lycopene were estimated from 24-hour dietary records. Visual Analogue Scale (VAS) and Western Ontario and McMaster (WOMAC) index were used to assess the pain and functional status, respectively. : Serum concentrations of alpha-tocopherol (  =  ) and lycopene (  =  ) were significantly lower in OA patients in comparison with healthy controls. Dietary intake of alpha-tocopherol was negatively associated with total WOMAC score (  =   =  ) and pain (  =   =  ) and physical function (  =   =  ) subscales. Dietary intake of lycopene was negatively associated with total WOMAC score (  =   <  ) and pain (  =   =  ) and physical function (  =   <  ) subscales. Additionally, serum concentration of alpha-tocopherol was negatively associated with total WOMAC score (  =   <  ) and physical function subscale (  =   <  ). Serum concentration of lycopene was negatively associated with total WOMAC score (  =   =  ) and physical function subscale (  =   =  ) : Serum concentrations of α-tocopherol and lycopene were significantly lower in patients with KOA than in healthy controls. Significant negative association was detected between serum concentration and dietary intake of α-tocopherol and lycopene with functional disability in patients with KOA.