In vitro activity of efrotomycin, ciprofloxacin, and six other antimicrobials against Clostridium difficile

The susceptibility of 69 clinical isolates of Clostridium difficile from the Minneapolis Veterans Administration Medical Center and 29 C. difficile strains from other hospitals to efrotomycin, ciprofloxacin, and six other antimicrobials was tested in vitro by agar dilution. Ciprofloxin (MIC 50 and M...

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Published inDiagnostic microbiology and infectious disease Vol. 6; no. 1; pp. 49 - 52
Main Authors Clabots, C.R., Shanholtzer, C.J., Peterson, L.R., Gerding, D.N.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 1987
Elsevier
Subjects
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Ciprofloxacin - pharmacology
Clostridium - drug effects
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Pyridones - pharmacology
Antibiotic
Sensitivity resistance
Drug susceptibility test
Clostridiaceae
Clostridium difficile
Minimum inhibitory concentration
Clostridiales
Bacteria
Erythromycin
Antibacterial agent
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Summary:The susceptibility of 69 clinical isolates of Clostridium difficile from the Minneapolis Veterans Administration Medical Center and 29 C. difficile strains from other hospitals to efrotomycin, ciprofloxacin, and six other antimicrobials was tested in vitro by agar dilution. Ciprofloxin (MIC 50 and MIC 90 = 8 mcg/ml) was only moderately active whereas efrotomycin (MIC 50 = 0.125, MIC 90 = 0.25 mcg/ml) was highly active against C. difficile .
Bibliography:ObjectType-Article-1
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ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(87)90113-1