Two new terpenoids and other constituents from Salvia cavaleriei and their antibacterial activities

Two previously undescribed terpenoids, named salviaterpenoid A (1) and ligurobustoside T (2), along with twenty known compounds (3–22) were isolated from Salvia cavaleriei Levl. Their structures were established based on extensive spectroscopic analyses, including HR-ESI-MS, 1D- and 2D NMR as well a...

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Published inPhytochemistry letters Vol. 53; pp. 137 - 141
Main Authors Zhao, Yu-Min, Li, Ke, Liu, Han-Fei, Li, Jin-Yu, Fu, Jian, Lou, Hua-Yong, Pan, Wei-Dong
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.02.2023
Subjects
Abietane diterpene
Antibacterial activities
Monoterpene glycoside
Salvia cavaleriei
Terpenes
Antibacterial activities
Monoterpene glycoside
Terpenes
Salvia cavaleriei
Abietane diterpene
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Summary:Two previously undescribed terpenoids, named salviaterpenoid A (1) and ligurobustoside T (2), along with twenty known compounds (3–22) were isolated from Salvia cavaleriei Levl. Their structures were established based on extensive spectroscopic analyses, including HR-ESI-MS, 1D- and 2D NMR as well as by comparison with the data reported in the literature. The absolute configuration of the new compound 1 was established by electronic circular dichroism (ECD). All isolates were tested for their antibacterial activities against Pseudomonas solanacearum, Clostridium perfringens, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Noteworthily, compound 19 showed appreciable antibacterial activity against B. subtilis with a minimum inhibitory concentration (MIC) value of 7.6 μg/mL. Moreover, compounds 18, 19, 21 and 22 exhibited significant antibacterial activities against B. subtilis, P. solanacearum and C. perfringens, with MICs ranging from 35 μg/mL to 60.8 μg/mL. [Display omitted] •Twenty-two compounds were isolated from a 95%-EtOH extract of Salvia cavaleriei Levl (Lamiaceae).•Two previously undescribed terpenoids were elucidated based on extensive spectroscopic analyses, as well as ECD calculations.•Ten compounds (1-4, 8, 11-15) were isolated for the first time from the genus Salvia.•Compound 19 showed appreciable antibacterial activity against B. subtilis with an MIC value of 7.6 μg/mL.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2022.12.009